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ALA antioxidant

Alpha Lipoic Acid

Alpha Lipoic Acid



Cellular Antioxidant


  • Promotes Healthy Heart Function
  • Benefits Neurological Health
  • Improves Oxidation Status
  • Enhances Blood Flow
  • Boosts Liver Health
  • 120 Servings






Alpha Lipoic Acid is a mitochondrial antioxidant with profound health effects. The mitochondria are the “powerhouse of the cell,” which means it is where ATP (cellular energy) is made. This is a great thing, as we need immense quantities of ATP. Reducing oxidation at the mitochondria level with ALA has the following effects.


  • ALA stimulates intracellular proteins to more efficiently burn body fat.*
  • Enhances Sirtuin protein expression. The Sirtuin protein family is responsible for ALA’s anti-aging effects.*
  • Supplementation with ALA has been documented to enhance glucose uptake into muscles, decreasing blood glucose while benefiting exercise performance.*
  • ALA helps form natural bioenergetic intermediates, improving energy production while simultaneously reducing mitochondria’s potential to release free radicals.*


Mitochondrial health is of paramount importance, especially as we age. Most maladies can be linked back to a metabolic origin, and the mitochondria are the epicenter of metabolism. As our mitochondria age, we age. With ALA’s antioxidant effects that occur primarily within the mitochondria, it is an excellent defense against aging, poor metabolic function, and cognitive decline.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



Supplement Facts

 Best Supplement for Mitochondria

Ingredient Profile

Alpha Lipoic Acid

ALA is a dithiol that is synthesized inside the mitochondria of human cells, principally within liver cells.


  • Decreases oxidation and inflammatory markers (IL-6, plasminogen activator-1)
  • Research has observed that ALA is capable of reducing blood glucose, depositing it in muscle cells
  • ALA may reduce appetite and lead to weight loss
  • Exerts an anti-aging effect by acting on Sirtuins

Q: What is the best way to use Alpha Lipoic Acid?

A: As a dietary supplement, take 1 serving (1 softgel) 1-2 times daily.


Q: Does Alpha Lipoic Acid need to be taken with food?

A: Although ALA is a fat-soluble molecule, it does not need to be taken with a meal.


Q: Are there any Optitune products that can be stacked with Alpha Lipoic Acid?

A: Yes! ALA pairs extremely well with L-Carnitine. The data on their synergistic effects indicate that using ALA and L-Carnitine together enhances their benefit to mitochondria by 100-1,000%! ALA also pairs well with Liver Support.



Alpha Lipoic Acid

  1. Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., & Khan, B. V. (2005). Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation111(3), 343-348.
  2. Xiang, G. D., Pu, J. H., Sun, H. L., & Zhao, L. S. (2010). Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Experimental and clinical endocrinology & diabetes118(09), 625-629.
  3. Martins, V. D., Manfredini, V., Peralba, M. C., & Benfato, M. S. (2009). Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients. Clinical nutrition28(2), 192-197.
  4. Ranieri, M., Sciuscio, M., Cortese, A. M., Santamato, A., Di Teo, L., Ianieri, G., ... & Megna, M. (2009). The Use and Alpha-Lipoic Acid (ALA), Gamma Linolenic Acid (GLA) and Rehabilitation in the Treatment of Back Pain: Effect on Health-Related Quality of Life. International journal of immunopathology and pharmacology22(3_suppl), 45-50.
  5. Porasuphatana, S., Suddee, S., Nartnampong, A., Konsil, J., Harnwong, B., & Santaweesuk, A. (2012). Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alphalipoic acid: a randomized double-blinded placebo-controlled study. Asia Pacific journal of clinical nutrition21(1), 12-21.
  6. Carbonelli, M. G., Renzo, L. D., Bigioni, M., Daniele, N. D., De Lorenzo, A., & Fusco, M. A. (2010). α-Lipoic acid supplementation: a tool for obesity therapy?. Current pharmaceutical design16(7), 840-846.
  7. Kim, M. S., Park, J. Y., Namkoong, C., Jang, P. G., Ryu, J. W., Song, H. S., ... & Lee, I. K. (2004). Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nature medicine10(7), 727.

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm -