Your Cart

FREE Shipping On All Domestic Orders!

0
Immunity+ Powder Immunity+ Powder

Immunity+ Powder

Immunity+ Powder

$34.99

$44.99

Maximum Immune Support

  • Strengthens the Immune System*
  • Super Antioxidant*
  • Boost Immune Cells*
  • 2,000IU Vitamin D3
  • 2 Delicious Flavors
  • 30 Servings

 

 

 

 

Description

Having a strong immune system is vital to good health and longevity. Supplementing for optimal immune function often leads people to a vitamin C supplement, but there are many other ways to improve immune health. In large part, immunity is improved by enhancing the health and number of white blood cells, resisting germs, and reducing oxidation to help offset feelings of unwellness.*

 

  • Vitamin C increases antioxidant enzyme activity, aids the immune system, and reduces harmful effects of stress.*
  • Astragalus activates the immune system by assisting white blood cells (B cells and T cells).*
  • Elderberry supplementation helps alleviate unwanted sensations.*
  • Olive extracts containing polyphenols which have shown efficacy for promoting favorable germ cell profiles.*
  • Echinacea increases macrophage ability to enhance adaptive immunity.*

 

Immunity+ focuses on providing fuel for the workers of the immune system – the antioxidants, macrophages, immunoglobulins, and other great fighting, health-boosting cells. Get back in the game, with Immunity+.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

 

Supplement Facts

 

Ingredient Profile

Vitamin A

Vitamin A is principally found in animal products such as meat, eggs, fish, and dairy as retinol. Provitamin A, carotenoids, are found in orange-colored plants – usually as beta-carotene, but there are over 600 known carotenoids.

 

  • Supports vision and prevents night blindness, xerophthalmia, and keratinization of the eye.
  • Helps with collagen formation for strong connective tissues and smooth skin.
  • Essential for reproduction by stimulating spermatogenesis, oogenesis, and embryonic growth.
  • Antioxidant within the cell membrane.

 

Vitamin C

The immunity vitamin. Vitamin C helps improve antioxidant status, and it has shown efficacy for reducing the duration and intensity of cold symptoms.

  • A vitamin C supplement can help reduce oxidative stress throughout the body.
  • In athletes, vitamin c supplementation has been observed to reduce upper respiratory tract infection duration, frequency, and severity.
  • Vitamin C supplementation can help mitigate the negative health effects of stress.

 

Vitamin D

Vitamin D is best known for improving bone health, and it has many other functions. Some of those functions include improving immune health.

  • Vitamin D helps improve macrophage (cells which “eat” pathogens, protecting the body) function by reducing their adhesion to the cell wall.
  • Increasing body vitamin D levels has been noted to reduce symptoms of autoimmune dysfunction.
  • Increases regulatory T cell and memory B cell counts.

 

Vitamin B6

Like the other B’s, B6 is heavily involved in energy metabolism. It is a cofactor in over 100 reactions, many of which within the muscle, where it helps with glycogen utilization.

 

  • Enhances muscle glycogen access and use.
  • Involved in heme synthesis.
  • Supports brain development and function.

 

Folic Acid

Folic acid, or folate, is the fetal vitamin (vitamin B9). Despite being known for healthy babies, folate has at least a dozen other functions. Here are a few:

 

  • Reduces incidence of neural tube defects during embryonic development.
  • Observational studies report reduced risk of various cancers.
  • Low folate levels are correlated with liver damage.

 

Calcium

Calcium is a common customer in milk and other dairy products. It’s one of the reasons milk is so effective for helping build muscle.

 

  • A signal for muscle contractions lasting longer than 20 seconds.
  • The major component of bones.
  • One of the primary electrolyte minerals.

 

Magnesium

Magnesium is involved in over 300 reactions throughout the body. Most of these reactions are tied to athletic performance in at least one way.

 

  • Magnesium participates in processes that generate ATP
  • Involved in protein synthesis.
  • Helps with muscle contractions.
  • Increases total work output.
  • Supplementation enhances endurance and peak oxygen consumption.

 

Zinc

Zinc is an essential mineral with many roles. It is one of the most important minerals for immune health.

  • Zinc is used to form superoxide dismutase, an antioxidant enzyme.
  • Zinc deficiencies are associated with immune dysfunction, among other complications.
  • Supplementing zinc at the onset of a cold and during other viral infections has been observed to reduce duration and severity of symptoms.

 

Astragalus Root

Astragalus is an herb used in traditional Chinese medicine. It is purported to have life extension effects.

  • Astragalus activates T cells to a greater extent than echinacea, which is independently capable of improving immune function.
  • Astragalus supplementation encourages proliferation of immune cells, immunoglobulins, and macrophages.
  • Collectively, this suggests enhanced adaptive immunity – a more specific and responsive type of immunity.

 

Elderberry

Elderberry is also known as Sambucus. There are several varieties of elderberry, but the most effective as a supplement is Sambucus nigra.

  • Elderberry is rich in nutrients such as vitamin C, fiber, polyphenols, and anthocyanins.
  • Supplementing with Elderberry relieves symptoms of influenza an average of 4 days faster than placebo.
  • Extracts of Elderberry also help fight bacteria, such as H. pylori.

 

N-Acetyl-Cysteine

N-Acetyl-Cysteine is an acetylated form of L-Cysteine that is more bioavailable. It is often used for its high antioxidant content to reduce inflammation and counter oxidative stress.

  • It also works to bind various free radicals and poisons in the body so they can be removed through the digestive process and expelled.

 

Olive Leaf Extract

Olives, and other parts of the plant contain several beneficial properties.

  • Components of olive leaf extract possess antiviral effects
  • Olive leaf may also be antibacterial against Staph infections

 

L-Lysine

Lysine is an essential amino acid. It has shown promise in combatting certain types of infections.

  • Lysine promotes absorption of certain minerals, such as calcium
  • As an arginine competitor, lysine may be effective at reducing the severity of herpes flare ups (Griffith, 1987).

 

Echinacea

Echinacea is often used at the first sign of sickness to help accelerate recovery and occasionally as a prophylaxis against colds.

  • Echinacea may stimulate macrophage production, helping fight pathogens.
  • A larger body of evidence suggest echinacea is effective for reducing the duration of sickness.

 

Spectra™

  • Decreases mitochondrial stress
  • Decreases reactive oxygen and reactive nitrogen species (free radicals)
  • Increases nitric oxide
  • Improves mitochondrial oxygen consumption

 

Grape Seed Extract

Grape seed has recently been discovered as a significant source of polyphenols and other antioxidants.

  • It has shown great promise for improving overall health, particularly cardiovascular health.
  • Using grape seed extract may be able to suppress inflammatory reactions to antigens, easing allergic symptoms.
FAQs

Q: What is the best way to use Immunity+?

A: As a dietary supplement, take 1 serving (1 capsule) daily to a stronger immune system.

 

Q: Does Immunity+ need to be taken with food?

A: For best absorption, use Immunity+ with food.

 

Q: Are there any Optitune products that can be stacked with Immunity+?

A: Yes! For the best improvements in immune function, use Immunity+ with Fruits and Greens.

 

References

Vitamin A

  1. Zile, M. H., & Cullum, M. E. (1983). The function of vitamin A: current concepts. Proceedings of the Society for Experimental Biology and Medicine, 172(2), 139-152.
  2. Dowling, J. E., & Wald, G. (1960). The biological function of vitamin A acid. Proceedings of the National Academy of Sciences, 46(5), 587-608.
  3. Ross, A. C., & Gardner, E. M. (1994). The function of vitamin A in cellular growth and differentiation, and its roles during pregnancy and lactation. In Nutrient Regulation during Pregnancy, Lactation, and Infant Growth(pp. 187-200). Springer, Boston, MA.

 

Vitamin C

  1. Kuiper, H. C., Bruno, R. S., Traber, M. G., & Stevens, J. F. (2011). Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans. Free Radical Biology and Medicine, 50(7), 848-853.
  2. Mastaloudis, A., Morrow, J. D., Hopkins, D. W., Devaraj, S., & Traber, M. G. (2004). Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biology and Medicine, 36(10), 1329-1341.
  3. Rafighi, Z., Shiva, A., Arab, S., & Yusuf, R. M. (2013). Association of dietary vitamin C and E intake and antioxidant enzymes in type 2 diabetes mellitus patients. Global journal of health science, 5(3), 183.
  4. Miller, J.Z., et al., Therapeutic effect of vitamin C: A co-twin control study. Jama, 1977. 237(3): p. 248-251.
  5. Ritzel, G., Letter: Ascorbic acid and the common cold. Vol. 235. 1976. 1108.
  6. Himmelstein, S.A., The effect of vitamin C supplementation on incidence of upper respiratory tract infections in marathon runners. 1997.
  7. Peters, E., et al., Vitamin C as effective as combinations of anti-oxidant nutrients in reducing symptoms of upper respiratory tract infection in ultramarathon runners. S Afr J Sports Med, 1996. 11(3): p. 23-7.
  8. Van Straten, M. and P. Josling, Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey. Advances in therapy, 2002. 19(3): p. 151-159.
  9. Nakhostin-Roohi, B., Babaei, P., Rahmani-Nia, F., & Bohlooli, S. (2008). Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO^ sub 2max^. Journal of Sports Medicine and Physical Fitness, 48(2), 217.

 

Vitamin D

  1. Urashima, M., Segawa, T., Okazaki, M., Kurihara, M., Wada, Y., & Ida, H. (2010). Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. The American journal of clinical nutrition, 91(5), 1255-1260.
  2. Abou-Raya, A., Abou-Raya, S., & Helmii, M. (2013). The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo-controlled trial. The Journal of rheumatology, 40(3), 265-272.
  3. Riek, A. E., Oh, J., Sprague, J. E., Timpson, A., de las Fuentes, L., Bernal-Mizrachi, L., ... & Bernal-Mizrachi, C. (2012). Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients. Journal of Biological Chemistry, 287(46), 38482-38494.
  4. Kim, G., & Bae, J. H. (2016). Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition, 32(9), 913-920.
  5. Martineau, A. R., Wilkinson, R. J., Wilkinson, K. A., Newton, S. M., Kampmann, B., Hall, B. M., ... & Rainbow, S. J. (2007). A single dose of vitamin D enhances immunity to mycobacteria. American journal of respiratory and critical care medicine, 176(2), 208-213.
  6. Adams, J. S., & Hewison, M. (2008). Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nature Reviews Endocrinology, 4(2), 80.
  7. Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., ... & Soni, M. (2013). Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmunity reviews, 12(10), 976-989.
  8. Terrier, B., Derian, N., Schoindre, Y., Chaara, W., Geri, G., Zahr, N., ... & Piette, J. C. (2012). Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis research & therapy, 14(5), R221.

 

Vitamin B6

  1. Denner, L. A., & Wu, J. Y. (1985). Two forms of rat brain glutamic acid decarboxylase differ in their dependence on free pyridoxal phosphate. Journal of neurochemistry, 44(3), 957-965.
  2. Zhuo, J. M., & Praticò, D. (2010). Acceleration of brain amyloidosis in an Alzheimer’s disease mouse model by a folate, vitamin B6 and B12-deficient diet. Experimental gerontology, 45(3), 195-201.
  3. RICHERT, D. A., & SCHULMAN, M. P. (1959). Vitamin interrelationships in heme synthesis. The American Journal of Clinical Nutrition, 7(4), 416-425.
  4. Hedrick, J. L., & Fischer, E. H. (1965). On the Role of Pyridoxal 5'-Phosphate in Phosphorylase. I. Absence of Classical Vitamin B6—dependent Enzymatic Activities in Muscle Glycogen Phosphorylase. Biochemistry, 4(7), 1337-1343.
  5. OKADA, M., ISHIKAWA, K., & WATANABE, K. (1991). Effect of vitamin B6 deficiency on glycogen metabolism in the skeletal muscle, heart, and liver of rats. Journal of nutritional science and vitaminology, 37(4), 349-357.

 

Folic Acid

  1. Welzel, T. M., Katki, H. A., Sakoda, L. C., Evans, A. A., London, W. T., Chen, G., ... & McGlynn, K. A. (2007). Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort. Cancer Epidemiology and Prevention Biomarkers, 16(6), 1279-1282.
  2. Shrubsole, M. J., Jin, F., Dai, Q., Shu, X. O., Potter, J. D., Hebert, J. R., ... & Zheng, W. (2001). Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer research, 61(19), 7136-7141.
  3. Su, L. J., & Arab, L. (2001). Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Annals of epidemiology, 11(1), 65-72.
  4. Wilson, R. D., Désilets, V., Wyatt, P., Langlois, S., Gagnon, A., Allen, V., ... & Koren, G. (2007). Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of obstetrics and gynaecology Canada, 29(12), 1003-1013.

 

Calcium

  1. Johnston Jr, C. C., Miller, J. Z., Slemenda, C. W., Reister, T. K., Hui, S., Christian, J. C., & Peacock, M. (1992). Calcium supplementation and increases in bone mineral density in children. New England journal of medicine, 327(2), 82-87.
  2. Reid, I. R., Ames, R. W., Evans, M. C., Gamble, G. D., & Sharpe, S. J. (1995). Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. The American journal of medicine, 98(4), 331-335.
  3. Ebashi, S., & Endo, M. (1968). Calcium and muscle contraction. Progress in biophysics and molecular biology, 18, 123-183.

 

Magnesium

  1. Food and Nutrition Board. (1997). Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and floride. Washington, DC: National Academy Press; 1997
  2. Volpe, S. L. (2015). Magnesium and the athlete. Current sports medicine reports, 14(4), 279-283.
  3. McDonald, R., & Keen, C. L. (1988). Iron, zinc and magnesium nutrition and athletic performance. Sports Medicine, 5(3), 171-184.
  4. Lukaski, H. C., & Nielsen, F. H. (2002). Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women. The Journal of nutrition, 132(5), 930-935.
  5. Vecchiet, L., Pieralisi, G., D’Ovidio, M., Dragani, L., Felzani, G., Mincarini, A., ... & Piovanelli, P. (1995). Effects of magnesium supplementation on maximal and submaximal effort. Magnesium and Physical Activity, 227-237.
  6. Brilla, L. R., & Gunther, K. B. (1995). Effect of magnesium supplementation on exercise time to exhaustion. Med Exerc Nutr Health, 4, 230-233.

 

Zinc

  1. Kelishadi, R., Hashemipour, M., Adeli, K., Tavakoli, N., Movahedian-Attar, A., Shapouri, J., ... & Rouzbahani, A. (2010). Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metabolic syndrome and related disorders, 8(6), 505-510.
  2. Bao, B., Prasad, A. S., Beck, F. W., Fitzgerald, J. T., Snell, D., Bao, G. W., ... & Cardozo, L. J. (2010). Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American journal of clinical nutrition, 91(6), 1634-1641.
  3. Kara, E., Gunay, M., Cicioglu, İ., Ozal, M., Kilic, M., Mogulkoc, R., & Baltaci, A. K. (2010). Effect of zinc supplementation on antioxidant activity in young wrestlers. Biological trace element research, 134(1), 55-63.
  4. Sharquie, K. E., Khorsheed, A. A., & Al-Nuaimy, A. A. (2007). Topical zinc sulphate solution for treatment of viral warts. Saudi Medical Journal, 28(9), 1418.
  5. Al‐Gurairi, F. T., Al‐Waiz, M., & Sharquie, K. E. (2002). Oral zinc sulphate in the treatment of recalcitrant viral warts: randomized placebo‐controlled clinical trial. British Journal of Dermatology, 146(3), 423-431.
  6. MUN, J. H., KIM, S. H., JUNG, D. S., KO, H. C., KIM, B. S., KWON, K. S., & KIM, M. B. (2011). Oral zinc sulfate treatment for viral warts: An open‐label study. The Journal of dermatology, 38(6), 541-545.
  7. Prasad, A. S. (2008). Zinc in human health: effect of zinc on immune cells. Molecular medicine, 14(5), 353-357.
  8. Prasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007). Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American journal of clinical nutrition, 85(3), 837-844.
  9. Abreu, I. A., & Cabelli, D. E. (2010). Superoxide dismutases—a review of the metal-associated mechanistic variations. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1804(2), 263-274.
  10. Singh, M., & Das, R. R. (2013). Zinc for the common cold. Cochrane Database of Systematic Reviews, (6).
  11. Baum, M. K., Lai, S., Sales, S., Page, J. B., & Campa, A. (2010). Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clinical Infectious Diseases, 50(12), 1653-1660.

 

Astragalus Root

  1. Cho, W. C. S., & Leung, K. N. (2007). In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. Journal of ethnopharmacology, 113(1), 132-141.
  2. Shao, B. M., Xu, W., Dai, H., Tu, P., Li, Z., & Gao, X. M. (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochemical and biophysical research communications, 320(4), 1103-1111.
  3. Du, X., Chen, X., Zhao, B., Lv, Y., Zhang, H., Liu, H., ... & Zeng, X. (2011). Astragalus polysaccharides enhance the humoral and cellular immune responses of hepatitis B surface antigen vaccination through inhibiting the expression of transforming growth factor β and the frequency of regulatory T cells. FEMS Immunology & Medical Microbiology, 63(2), 228-235.
  4. Barak, V., Halperin, T., & Kalickman, I. (2001). The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw, 12(2), 290-296.

 

Elderberry

  1. Zakay-Rones, Z., Thom, E., Wollan, T., & Wadstein, J. (2004). Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. Journal of International Medical Research, 32(2), 132-140.
  2. Tiralongo, E., Wee, S., & Lea, R. (2016). Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients, 8(4), 182.
  3. Barak, V., Halperin, T., & Kalickman, I. (2001). The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw, 12(2), 290-296.
  4. Zakay-Rones, Z., Varsano, N., Zlotnik, M., Manor, O., Regev, L., Schlesinger, M., & Mumcuoglu, M. (1995). Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. The Journal of Alternative and Complementary Medicine, 1(4), 361-369.
  5. Sidor, A., & Gramza-Michałowska, A. (2015). Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food–a review. Journal of functional foods, 18, 941-958.
  6. Porter, R. S., & Bode, R. F. (2017). A review of the antiviral properties of black elder (Sambucus nigra L.) products. Phytotherapy Research, 31(4), 533-554.

 

N-Acetyl-Cysteine

  1. Holdiness, M. R. (1991). Clinical pharmacokinetics of N-acetylcysteine.Clinical pharmacokinetics, 20(2), 123-134.
  2. Wang, L., Wang, Z., & Liu, J. (2010). Protective effect of N-acetylcysteine on experimental chronic lead nephrotoxicity in immature female rats. Human & experimental toxicology, 29(7), 581-591.
  3. Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Ostałowska, A., & Birkner, E. (2013). The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead. Clinical Toxicology, 51(6), 480-486.
  4. Kasperczyk, A., Słowińska-Łożyńska, L., Dobrakowski, M., Zalejska-Fiolka, J., & Kasperczyk, S. (2014). The effect of lead-induced oxidative stress on blood viscosity and rheological properties of erythrocytes in lead exposed humans. Clinical hemorheology and microcirculation, 56(3), 187-195.

 

Olive Leaf Extract

  1. Renis, H. E. (1969). In vitro antiviral activity of calcium elenolate. Antimicrobial agents and chemotherapy, 9, 167.
  2. Ali, N. H., Faizi, S., & Kazmi, S. U. (2011). Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan. Pharmaceutical biology, 49(8), 833-839.
  3. Sudjana, A. N., D’Orazio, C., Ryan, V., Rasool, N., Ng, J., Islam, N., ... & Hammer, K. A. (2009). Antimicrobial activity of commercial Olea europaea (olive) leaf extract. International journal of antimicrobial agents, 33(5), 461-463.

 

L-Lysine

  1. Griffith, R. S., Walsh, D. E., Myrmel, K. H., Thompson, R. W., & Behforooz, A. (1987). Success of L-lysine therapy in frequently recurrent herpes simplex infection. Dermatology, 175(4), 183-190.
  2. McCune, M. A., Perry, H. O., Muller, S. A., & O'Fallon, W. M. (1984). Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis, 34(4), 366-373.
  3. Dawson-Hughes, B., Harris, S. S., Rasmussen, H. M., & Dallal, G. E. (2007). Comparative effects of oral aromatic and branched-chain amino acids on urine calcium excretion in humans. Osteoporosis international, 18(7), 955-961.
  4. Busque, S. M., Kerstetter, J. E., Geibel, J. P., & Insogna, K. (2005). L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289(4), G664-G669.

 

Echinacea

  1. Zwickey, H., Brush, J., Iacullo, C. M., Connelly, E., Gregory, W. L., Soumyanath, A., & Buresh, R. (2007). The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(11), 1109-1112.
  2. Schoop, R., Klein, P., Suter, A., & Johnston, S. L. (2006). Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clinical Therapeutics, 28(2), 174-183.
  3. Grimm, W., & Müller, H. H. (1999). A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. The American journal of medicine, 106(2), 138-143.
  4. Shah, S. A., Sander, S., White, C. M., Rinaldi, M., & Coleman, C. I. (2007). Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. The Lancet infectious diseases, 7(7), 473-480.
  5. Tiralongo, E., Lea, R. A., Wee, S. S., Hanna, M. M., & Griffiths, L. R. (2012). Randomised, double blind, placebo-controlled trial of Echinacea supplementation in air travellers. Evidence-Based Complementary and Alternative Medicine, 2012.
  6. Jawad, M., Schoop, R., Suter, A., Klein, P., & Eccles, R. (2012). Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine, 2012.
  7. Rehman, J., Dillow, J. M., Carter, S. M., Chou, J., Le, B., & Maisel, A. S. (1999). Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunology letters, 68(2-3), 391-395.

 

Spectra

  1. Steffen, L. M., Jacobs Jr, D. R., Stevens, J., Shahar, E., Carithers, T., & Folsom, A. R. (2003). Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. The American journal of clinical nutrition, 78(3), 383-390.
  2. Limmer, M., Eibl, A. D., & Platen, P. (2018). Enhanced 400-m sprint performance in moderately trained participants by a 4-day alkalizing diet: a counterbalanced, randomized controlled trial. Journal of the International Society of Sports Nutrition, 15(1), 25.

 

Grape Seed Extract

  1. Tang, Q., Zou, P., Jin, H., Fu, J., Yang, J., Shang, L., & Wei, X. (2012). Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2, 4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro. Toxicology letters, 210(1), 1-8.
  2. Romier-Crouzet, B., Van De Walle, J., During, A., Joly, A., Rousseau, C., Henry, O., ... & Schneider, Y. J. (2009). Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Food and Chemical Toxicology, 47(6), 1221-1230.
  3. Velmurugan, B., Singh, R. P., Kaul, N., Agarwal, R., & Agarwal, C. (2010). Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia (New York, NY), 12(1), 95.
  4. Li, X. L., Cai, Y. Q., Qin, H., & Wu, Y. J. (2008). Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis. Canadian journal of physiology and pharmacology, 86(12), 841-849.
  5. Terra, X., Valls, J., Vitrac, X., Mérrillon, J. M., Arola, L., Ardèvol, A., ... & Blay, M. (2007). Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. Journal of agricultural and food chemistry, 55(11), 4357-4365.

 

WARNING

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm - www.P65warnings.ca.gov/