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Lion's Mane

Lion's Mane



Memory & Nervous System Support


  • Improve Neuroplasticity*
  • Reduce Oxidative Stress*
  • Boost Cognition*
  • Enhance Memory*
  • 30 Servings



Lion’s Mane mushroom has a very unique appearance that looks just like a lion’s mane. Just as its appearance goes, so goes its effects. Lion’s Mane mushroom is one of the only mushrooms with strong cognitive benefits. The active components of Lion’s Mane have been shown to offer neuroprotective, cognitive-enhancing, and mood-boosting effects.


  • Attenuates over-excitatory effects of glutamate
  • Protects neurons from excessive stress
  • Improves cognitive abilities


Optitune’s Lion’s Mane NRG contains 2,000mg of organic Lion’s Mane Mushroom as well as 50mg of caffeine, yerba matte, green tea, and theanine. These 4 ingredients help the user reap all the benefits of Lion’s Mane by providing a little bit of energy, anxiolysis (anti-anxiety), and memory enhancement.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



Supplement Facts

 Best Nootropic

Ingredient Profile

Lion’s Mane

A special type of mushroom containing active components Hericenones, Erinacines, and antioxidants.

  • Improves neuron health by reducing overstimulation, promoting regeneration, and limiting stress.
  • Has antioxidant effects
  • Helps with managing lipids and metabolism


Caffeine Anhydrous

Caffeine Anhydrous is simply caffeine with no water (around .05%). This has been shown to make caffeine anhydrous more potent because the body will absorb it more readily.

  • Although caffeine can affect a wide variety of motor and mental functions it is most commonly used to improve endurance exercise, focus, and cognitive performance, and improve energy levels.
  • Caffeine has also been shown to have a thermogenic effect (heating/calorie burning) at rest and may increase the use of fats for fuel during exercise.
  • According to the research higher doses of caffeine, in the 250-450mg range, are needed to provide an ergogenic benefit.
  • In a study conducted by Astorino et al. (2010), active men given caffeine before resistance training were able to increase maximal torque, power, and volume by 5-8%.


Yerba Matte

Yerba matte is a south American plant that offers the stimulatory effects of coffee with the health benefits of tea. It contains caffeine, theobromine, theophylline, and numerous antioxidants.

  • Yerba Matte may prevent lipid oxidation, which decreases the number of free radicals produced in the body.
  • It has been shown to reduce fat as well as lower LDL cholesterol.
  • Human studies have shown a reduction in inflammation when supplementing with Yerba Matte.
  • A 2009 study performed by the Federal University of Santa Catarina noted Yerba Mate ingestion for 20-40 days, in healthy individuals, was shown to reduce body fat content as well as lower LDL cholesterol. In turn, the reduction of body fat and LDL cholesterol levels aided in lowering systolic blood pressure.


Green Tea

Green Tea Extract is an herbal derivative from green tea leaves, containing antioxidant ingredients and thermogenic compounds.

  • This extract contains high amounts of catechins, including EGCG which helps with the metabolism of fat at rest and during exercise performance.
  • Green tea also reduces the formation of free radicals in the body which protect cells and molecules from damage.
  • A meta-analysis of 11 studies looking at green tea consumption over a period of 12 weeks’ minimum noted, on average, 1.31kg weight loss.



L-Theanine is an amino acid, that when consumed produces GABA, a neurotransmitter which acts on the brain to reduce the perceived stress.

  • Research suggests that L-Theanine’s biggest supplemental role may be in taking the “edge” off of other stimulants.
  • A combination of L-Theanine with caffeine is noted to be synergistic in promoting thermogenesis, cognition, and attention.
  • Giesbrecht et al. found the combination of L-theanine and caffeine significantly improved accuracy during task switching, self-reported alertness, and reduced self-reported tiredness.

Q: What is the best way to use Lion’s Mane NRG?

A: As a dietary supplement, take 1 serving (3 capsules) as needed to improve cognition.


Q: Does Lion’s Mane NRG need to be taken with food?

A: For best absorption, use Lion’s Mane NRG on an empty stomach.


Q: Are there any Optitune products that can be stacked with Lion’s Mane NRG?

A: Yes! Use Lion’s Mane NRG along with Optitune's Alpha-GPC for a great nootropic combination.



Lion’s Mane

  1. Wong, K. H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers.(Aphyllophoromycetideae). Evidence-based complementary and alternative medicine2011.
  2. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives23(3), 367-372.
  3. Kolotushkina, E. V., Moldavan, M. G., Voronin, K. Y., & Skibo, G. G. (2003). The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh49(1), 38-45.
  4. Ueda, K., Tsujimori, M., Kodani, S., Chiba, A., Kubo, M., Masuno, K., ... & Kawagishi, H. (2008). An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorganic & medicinal chemistry16(21), 9467-9470.
  5. Moldavan, M., Grygansky, A. P., Kolotushkina, O. V., Kirchhoff, B., Skibo, G. G., & Pedarzani, P. (2007). Neurotropic and trophic action of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers.(Aphyllophoromycetideae) extracts on nerve cells in vitro. International Journal of Medicinal Mushrooms9(1).


Caffeine Anhydrous

  1. Doherty, M., & Smith, P. M. (2004). Effects of caffeine ingestion on exercise testing: a meta-analysis. International journal of sport nutrition and exercise metabolism, 14(6), 626-646.
  2. Astorino, T. A., & Roberson, D. W. (2010). Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review. The Journal of Strength & Conditioning Research, 24(1), 257-265.
  3. Simmonds, M. J., Minahan, C. L., & Sabapathy, S. (2010). Caffeine improves supramaximal cycling but not the rate of anaerobic energy release. European journal of applied physiology, 109(2), 287-295.
  4. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 51(5), 759-767.
  5. Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A., & Miller, D. S. (1989). Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American journal of clinical nutrition, 49(1), 44-50.


Yerba Matte

  1. Bracesco, N., Sanchez, A. G., Contreras, V., Menini, T., & Gugliucci, A. (2011). Recent advances on Ilex paraguariensis research: minireview.Journal of ethnopharmacology, 136(3), 378-384.
  2. De Morais, E. C., Stefanuto, A., Klein, G. A., Boaventura, B. C., De Andrade, F., Wazlawik, E., ... & da Silva, E. L. (2009). Consumption of yerba mate (Ilex paraguariensis) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. Journal of agricultural and food chemistry,57(18), 8316-8324.
  3. Arçari, D. P., Bartchewsky, W., Santos, T. W., Oliveira, K. A., Funck, A., Pedrazzoli, J., ... & Carvalho, P. D. O. (2009). Antiobesity Effects of yerba maté Extract (Ilex paraguariensis) in High‐fat Diet–induced Obese Mice.Obesity, 17(12), 2127-2133.
  4. Matsumoto, R. L., Bastos, D. H., Mendonça, S., Nunes, V. S., Bartchewsky Jr, W., Ribeiro, M. L., & de Oliveira Carvalho, P. (2009). Effects of mate tea (Ilex paraguariensis) ingestion on mRNA expression of antioxidant enzymes, lipid peroxidation, and total antioxidant status in healthy young women.Journal of agricultural and food chemistry, 57(5), 1775-1780.
  5. Da Silva, E. L., Neiva, T. J., Shirai, M., Terao, J., & Abdalla, D. S. (2008). Acute ingestion of yerba mate infusion (Ilex paraguariensis) inhibits plasma and lipoprotein oxidation. Food Research International, 41(10), 973-979.


Green Tea Extract

  1. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. Outlaw J, Wilborn C, Smith A, Urbina S, Hayward S. J Int Soc Sports Nutr. 2013 Apr 30;10(1):25.
  2. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Am J Clin Nutr. 1999 Dec;70(6):1040-5
  3. Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study. Mirza B, Ikram H, Bilgrami S, Haleem DJ, Haleem MA. Pak J Pharm Sci. 2013 May;26(3):511-6.
  4. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Hodgson AB, Randell RK, Jeukendrup AE. Adv Nutr. 2013 Mar 1;4(2):129-40.
  5. Metabolic response to green tea extract during rest and moderate-intensity exercise. Hodgson AB, Randell RK, Boon N, Garczarek U, Mela DJ, Jeukendrup AE, Jacobs DM. J Nutr Biochem. 2013 Jan;24(1):325-34.



  1. Park, S. K., Jung, I. C., Lee, W. K., Lee, Y. S., Park, H. K., Go, H. J., ... & Rho, S. S. (2011). A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. Journal of medicinal food, 14(4), 334-343.
  2. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198.
  3. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283-290.



California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm -