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best liver detox

Liver Support

Liver Support

$24.99

Advanced Liver Support

 

  • Promotes Resistance to Oxidation and Pro-Inflammatory Cytokines
  • Enhances Liver Function*
  • Helps the Liver During Digestion*
  • Assists Natural Liver Enzymes*
  • 60 Servings

 

 

 

Description

The liver is an incredibly important organ. It doesn’t get as much credit as it deserves – the liver is responsible for over 500 different health functions. Principally, the liver is in charge of digestion, metabolism, and detoxification. With modern medicine, a profit-driven food system, alcohol consumption, and/or environmental toxins, our livers get by with a little help from their friends:

 

  • Milk Thistle Extract - A liver therapeutic compound that may increase the rate of protein synthesis in liver cells and encourage subsequent repair after injury to the cells.*
  • L-Glutathione - Heavily involved in the detoxification of our body, so it is no surprise that it is found in its highest concentrations in the liver.*
  • Tumeric Extract - Turmeric can uniquely assist the enzymes that are responsible for flushing out known dietary carcinogens. The result is enhanced protection against liver damage, and even regeneration of affected liver cells.*
  • Artichoke Powder - This extract appears to have the ability to stimulate bile secretion and benefits the liver by helping it to eliminate toxins.*

 

Each of these ingredients and more are found in Liver Support, a full-strength, full-spectrum liver health booster. The liver is one of the body’s hardest working organs. Help it out a little with Liver Support! Your best option for detoxification, purification, and protection.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

 Best Supplement for Liver

Ingredient Profile

Milk Thistle Extract

Milk thistle is an herb that may be a liver therapeutic compound.

 

  • Milk thistle may increase the rate of protein synthesis in liver cells and encourage subsequent repair after injury to the cells.
  • It may also decrease LDL, triglycerides, and heartburn.
  • Limited evidence exists, but milk thistle may also have anti-obesity effects.

 

N-Acetyl Cysteine

N-Acetyl-Cysteine is an acetylated form of L-Cysteine that is more bioavailable. It is often used for its high antioxidant content to reduce inflammation and counter oxidative stress.

 

  • It also works to bind various free radicals and poisons in the body so they can be removed through the digestive process and expelled.

 

L-Glutathione

Glutathione is a substance produced naturally by the liver. It is also found in fruits, vegetables, and meats.

 

  • Glutathione is involved in many processes in the body, including tissue building and repair, making chemicals and proteins needed in the body, and for the immune system.
  • Because glutathione is heavily involved in the detoxification of our body, it is no surprise that it is found in its highest concentrations in the liver; the body’s most important detoxifying organ.
  • Glutathione is also closely linked to liver health and function when GSH levels are high, the workload put on the liver is reduced and it has a chance to repair itself.
  • This helps reduce liver inflammation which is the cause of liver cirrhosis and impaired liver function.

 

Tumeric Extract

Turmeric is an herb that is used to help fight infections, reduce inflammation, and treat digestive problems.

 

  • Tumeric is also a potent antioxidant and may decrease symptoms of osteoarthritis.
  • What’s more, turmeric can uniquely assist the enzymes that are responsible for flushing out known dietary carcinogens. The result is enhanced protection against liver damage, and even regeneration of affected liver cells.
  • According to a new study in the Journal of the Medical Association of Thailand, scientists have found that the livers of diabetic rats were repaired and even regenerated with the help of turmeric.

 

Alpha Lipoic Acid

Alpha-Lipoic Acid (ALA) is a mitochondrial fatty acid that is highly involved in energy metabolism. It is synthesized in the body and can be consumed through eating meats and minimally in some fruits/vegetables.

 

  • In supplement form, ALA has shown as a benefit against various forms of oxidation and inflammation. These effects carry on to benefits that protect one from heart diseases, liver diseases, diabetes, and neurological decline with age.
  • ALA is also a potent anti-oxidant compound. It works with mitochondria and the body’s natural antioxidant defenses.
  • It is also seen as an anti-aging compound since it can reverse some of the oxidant damage related effects of aging.

 

KIDNEY SUPPORT MATRIX

 

Dandelion Root

Taraxacum officinale, also known as dandelion, is a vegetable that has a diuretic (water loss) effect when ingested.

 

  • It is also a source of potassium and thereby helps replace diuresis-induced losses.
  • Dandelion may help ease digestion by increasing the rate at which food leaves the stomach and enters the small intestine.
  • A study conducted by Clare et al. (2009) found dandelion three times a day in otherwise healthy subjects reported an increase in urination frequency relative to the same subjects the day before and after supplementation.

 

Uva-Ursi

Uva-Ursi is an herbal compound which has the effects of a mild diuretic and astringent (anti-inflammatory).

 

  • It helps to reduce accumulation of uric acid in the bladder and help the overall health and productivity of the urinary tract.
  • Uva-Ursi may also help reduce high blood pressure and bloating.
  • Its anti-inflammatory effects can help to tighten upper layers of the mucous membrane – relieving irritation and improving tissue firmness.

 

L-Glycine

Glycine is a non-essential amino acid that is used to help generate muscle tissue, assist with proper cell growth and production, and convert glycogen into energy. It also plays an important role in proper nervous system function.

 

  • Glycine is required for the biosynthesis of creatine. Glycine increases the body’s creatine levels and helps prevent the breakdown of muscle.
  • In the absence of glycine, damaged muscle tissue cannot be repaired.
  • Current research has suggested that glycine supplementation may increase growth hormone (GH) levels 3-4 hours post-exercise via its stimulatory agents acting upon the pituitary gland. This increase in GH theoretically could lead to faster recovery times and greater muscle growth.

 

Juniper Berry

Juniper extract helps fight inflammation and various GI issues including upset stomach, heartburn, flatulence, bloating, and loss of appetite.

 

  • Juniper extract has been used as a diuretic. This activity is most likely due to the action of terpinen-4-ol, which is known to increase renal glomerular filtration rate.

 

Buchu Powder

Buchu is harvested from the dried leaves obtained from three species of Barosma.

 

  • Historically, buchu has been used to treat inflammation, kidney and urinary tract infections; and as a diuretic.

 

Artichoke Powder

Artichoke powder is an extract that appears to have the ability to stimulate bile secretion; this may underlie a reduction in cholesterol and improve fat digestion.

 

  • Artichoke is used to stimulate the flow of bile from the liver.
  • The bile production, stimulated by the artichoke leaf extract, benefits the liver by helping it to eliminate toxins.
  • One study in persons with high cholesterol has noted decreases in liver enzymes associated with artichoke supplementation, where over 45 days a decrease was seen for y-GT (25.8%), AST (17.3%), and ALT (15.2%) with no influence on GLDH.
FAQs

Q: What is the best way to take Liver Support?

A: As a dietary supplement, take one serving (1 Capsule) upon waking. For optimal performance, take an additional serving before bed.

 

Q: What physiological functions does the liver serve in the body?

A: The liver plays over 500 roles in the human body but the most important roles are the liver cleans your blood, metabolizes nutrients, produces a digestive liquid called bile, and stores energy in the form of glycogen.

 

Q: What other Optitune products do you recommend stacking with Liver Support?

A: To promote overall health we recommend stacking Liver Support with TUDCA, Adrenal Support, and Omega 3 Softgels.

References

Milk Thistle Extract

  1. Mulrow, C., Lawrence, V., Jacobs, B., Dennehy, C., Sapp, J., Ramirez, G., ... & Chiquette, E. (2000). Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary.
  2. Abenavoli, L., Capasso, R., Milic, N., & Capasso, F. (2010). Milk thistle in liver diseases: past, present, future. Phytotherapy Research, 24(10), 1423-1432.
  3. Pradhan, S. C., & Girish, C. (2006). A hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research, 124(5), 491.

 

N-Acetyl Cysteine

  1. Holdiness, M. R. (1991). Clinical pharmacokinetics of N-acetylcysteine. Clinical pharmacokinetics, 20(2), 123-134.
  2. Wang, L., Wang, Z., & Liu, J. (2010). Protective effect of N-acetylcysteine on experimental chronic lead nephrotoxicity in immature female rats. Human & experimental toxicology, 29(7), 581-591.
  3. Kasperczyk, S., Dobrakowski, M., Kasperczyk, A., Ostałowska, A., & Birkner, E. (2013). The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead. Clinical Toxicology, 51(6), 480-486.
  4. Kasperczyk, A., Słowińska-Łożyńska, L., Dobrakowski, M., Zalejska-Fiolka, J., & Kasperczyk, S. (2014). The effect of lead-induced oxidative stress on blood viscosity and rheological properties of erythrocytes in lead-exposed humans. Clinical hemorheology and microcirculation, 56(3), 187-195.

 

L-Glutathione

  1. Amano J, Suzuki A, Sunamori M. Salutary effect of reduced glutathione on renal function in coronary artery bypass operation. J Am Coll Surg 1994;179:714-20. View abstract.
  2. Amores-Sanchez MI, Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 1999;67:100-5. View abstract.
  3. Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 1998;24;111-112:1-14.
  4. Antioxidant lozenge could help ward off flu. www.reutershealth.com (Accessed 19 April 2000).
  5. Aw TY, Wierzbicka G, Jones DP. Oral glutathione increases tissue glutathione in vivo. Chem Biol Interact 1991;80:89-97. View abstract.
  6. Bains JS, Shaw CA. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Brain Res Rev 1997;25:335-58. View abstract.
  7. Borok Z, Buhl R, Grimes GJ, et al. Effect of glutathione aerosol on an oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet 1991;338:215-6. View abstract.

 

Tumeric Extract

  1. DiSilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle-aged people. Nutrition Journal, 11(1), 1.
  2. Chainani-Wu, N., Madden, E., Lozada-Nur, F., & Silverman, S. (2012). High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. Journal of the American Academy of Dermatology, 66(5), 752-760.
  3. Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., ... & Appendino, G. (2010). Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev, 15(4), 337-44.
  4. Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., ... & Yamada, M. (2006). Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology, 4(12), 1502-1506.
  5. Di Pierro, F., Rapacioli, G., Di Maio, E. A., Appendino, G., Franceschi, F., & Togni, S. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva (®)), nimesulide, and acetaminophen. J Pain Res, 6, 201-205.

 

Alpha Lipoic Acid

 

  1. McNeilly, A. M., Davison, G. W., Murphy, M. H., Nadeem, N., Trinick, T., Duly, E., ... & McEneny, J. (2011). Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance. Lipids in health and disease, 10(1), 1.
  2. Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., Stefaniak, T., & Dziubek, W. (2009). Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol, 60(2), 139-43.
  3. Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., & Khan, B. V. (2005). Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome results of the irbesartan and lipoic acid in endothelial dysfunction (island) study. Circulation, 111(3), 343-348.
  4. Ranieri, M., Sciuscio, M., Cortese, A. M., Santamato, A., Di Teo, L., Ianieri, G., ... & Megna, M. (2009). The Use and Alpha-Lipoic Acid (ALA), Gamma Linolenic Acid (GLA) and Rehabilitation in the Treatment of Back Pain: Effect on Health-Related Quality of Life. International journal of immunopathology and pharmacology, 22(3 suppl), 45-50.

 

Dandelion Root

  1. Lee et al. 2012; Effects of Taraxacum officinale on fatigue and immunological parameters in mice.
  2. Jeon et al. 2008; the Anti-inflammatory activity of Taraxacum officinale.
  3. Choi et al. 2010; Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.
  4. Turski et al. 2011; Distribution, synthesis, and absorption of kynurenic acid in plants.
  5. Domitrovic et al. 2010; Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice.
  6. Chatterjee et al 2011; The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. 7. Ovadje et al 2012; Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells.

 

Uva-Ursi

  1. Beaux D, Fleurentin J, Mortier F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother Res. 1999;13(3):222-5.
  2. Chauhan B, Yu C, Krantis A, Scott I, Arnason JT, Marles RJ, Foster BC. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
  3. Grases F, Melero G, Costa-Bauza A, Prieto R, March JG Urolithiasis and phytotherapy. Int Urol Nephrol. 1994;26(5):507-11.
  4. Head KA. Natural approaches to prevention and treatment of infections of the lower urinary tract. Altern Med Rev. 2008;13(3):227-44.
  5. Larsson B, Jonasson A, Fianu S. Prophylactic effect of UVA-E in women with recurrent cystitis: a preliminary report. Curr Ther Res. 1993;53:441-3.
  6. Matsuda H, Nakamura S, Tanaka T, Kubo M. [Pharmacological studies on leaf of arctostaphylos uva-ursi (L.) Spreng. V. Effects of water extract from arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) on the antiallergic anti-inflammatory activities of dexamethasone ointment.] Yakugaku Zasshi - J Pharm Soc Jpn. 1992;112(9):673-7.
  7. Matsuda H, Nakata H, Tanaka T, Kubo M. [a Pharmacological study on Arctostaphylos uva-ursi (L.) Spreng. II. Combined effects of arbutin and prednisolone or dexamethasone on immuno-inflammation] Yakugaku Zasshi. 1990;110(1):68-76.

 

L-Glycine

  1. Wax, B., Hilton, L., Vickers, B., Gilliland, K., & Conrad, M. (2013). Effects of glycine-arginine-alpha-ketoisocaproic acid supplementation in college-age trained females during multi-bouts of resistance exercise. J Diet Suppl, 10(1), 6-16.
  2. Nelson, M. J., Harris, M. B., Boluyt, M. O., Hwang, H. S., & Starnes, J. W. (2011). Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations. [Research Support, Non-U.S. Gov't]. Am J Physiol Regul Integr Comp Physiol, 300(4), R993-R1000..
  3. Jacobs, P. L., & Goldstein, E. R. (2010). Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance. J Int Soc Sports Nutr, 7, 35. doi: 10.1186/1550-2783-7-35
  4. Bloomer, R. J., Tschume, L. C., & Smith, W. A. (2009). Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. [Randomized Controlled Trial Research Support, Non-U.S. Gov't]. Int J Vitam Nutr Res, 79(3), 131-141.
  5. Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., & Hughes, J. J. (2009). Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr, 6, 9. doi: 10.1186/1550-2783-6-9

 

Juniper Berry

  1. Bisset, NG. Juniper fructus. 1994;283-285.
  2. Janku, I., Hava, M., and Motl, O. [Diuretic substance from juniper (Juniperus communis L.)]. Experientia 6-15-1957;13(6):255-256.
  3. Stanic, G, Samarzija, I, and Blazevic, N. Time-dependent diuretic response in rats treated with juniper berry preparations. Phytother Res 1998;12:494-497.

 

Buchu Powder

  1. Ernst E. Interactions between synthetic and herbal medicinal products Part 1: a systematic review of the indirect evidence. Perfusion 2000;13:4-15.
  2. Lis-Balchin, M., Hart, S., and Simpson, E. Buchu (Agathosma betulina and A. crenulata, Rutaceae) essential oils: their pharmacological action on guinea-pig ileum and antimicrobial activity on microorganisms. J Pharm.Pharmacol. 2001;53(4):579-582
  3. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

 

Artichoke Powder

  1. Fintelmann V. Antidyspeptic and lipid-lowering effects of artichoke leaf extract - results of clinical studies into the efficacy and tolerance of Hepar-SL forte involving 553 patients. J Gen Med 1996;2:3-19.
  2. Fintelmann V. Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties. Phytomedicine 1996;suppl 1:50.
  3. Gebhardt R and Fausel M. Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Toxicol in Vitro 1997;11:669-672.
  4. Hammerl, H. and Pichler, O. [Possibility of causal treatment of bile duct diseases with an artichoke preparation.]. Wien.Med Wochenschr. 6-29-1957;107(25-26):545-546
  5. Kiso, Y., Tohkin, M., and Hikino, H. Antihepatotoxic principles of Atractylodes rhizomes. J Nat.Prod. 1983;46(5):651-654
WARNING

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm - www.P65warnings.ca.gov/