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 Cellular Support


  • Supports Metabolism
  • Cellular Energy Support
  • Benefits Heart Health
  • Detoxifies Glutamate
  • 30 Servings



Oxaloacetate (OAA) is a bioenergetic intermediate. As part of the Kreb’s Cycle, OAA helps turn carbohydrates, fats, and amino acids into utilizable energy as ATP. Glutamate is an excitatory neurotransmitter than can cause neuronal damage at high concentrations. OAA acts as a glutamate scavenger, and OAA supplementation may provide neuroprotection in the presence of excess glutamate. Added vitamin C assists in free radical scavenging.



*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Best Oxaloacetic Acid Supplement

Ingredient Profile


Oxaloacetate is an intermediate in the citric acid (Kreb’s) cycle, which supplies energy and keeps cells healthy.

  • OAA is a glutamate scavenger, detoxifying harmful glutamate
  • This helps protect neurons to promote health brain and nervous system function
  • Enhances mitochondrial biogenesis
  • Increases longevity


Vitamin C

Vitamin C is a water-soluble vitamin with roles in antioxidation and immune health

  • Helps protect from colds by strengthening the immune system
  • Speeds recovery from infection
  • Repairs cartilage, bones, and teeth by facilitating collagen production
  • Protects the body from free radicals



Q: What is the best way to use Oxaloacetate™?

A: As a dietary supplement, consume 1 serving (1 capsule) of Oxaloacetate™ once daily.


Q: How does Oxaloacetate reduce glutamate?

A: Oxaloacetate is a key substrate for the glutamate-oxaloacetate transaminase enzyme. Only with oxaloacetate can the enzyme convert glutamate into 2-ketoglutarate (a ketone body that can be converted to alpha-ketoglutarate, another Kreb’s cycle intermediate), aspartate (amino acid), and alanine (amino acid).



  1. Zlotnik, A., Sinelnikov, I., Gruenbaum, B. F., Gruenbaum, S. E., Dubilet, M., Dubilet, E., ... & Shapira, Y. (2012). Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats. Anesthesiology: The Journal of the American Society of Anesthesiologists116(1), 73-83.
  2. Williams, D. S., Cash, A., Hamadani, L., & Diemer, T. (2009). Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway. Aging cell8(6), 765-768.
  3. Wilkins, H. M., Harris, J. L., Carl, S. M., E, L., Lu, J., Eva Selfridge, J., ... & Burns, J. M. (2014). Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Human molecular genetics23(24), 6528-6541.
  4. Zlotnik, A., Gruenbaum, S. E., Artru, A. A., Rozet, I., Dubilet, M., Tkachov, S., ... & Teichberg, V. I. (2009). The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. Journal of neurosurgical anesthesiology21(3), 235-241.
  5. Gottlieb, M., Wang, Y., & Teichberg, V. I. (2003). Blood‐mediated scavenging of cerebrospinal fluid glutamate. Journal of neurochemistry87(1), 119-126.

Vitamin C

  1. Moyad, M. A., & Combs, M. A. (2007). Vitamin C Dietary Supplements: An Objective Review of the Clinical Evidence. Parts I-III. In Seminars in Preventive and Alternative Medicine. Elsevier Inc..
  2. Stone, N., & Meister, A. (1962). Function of ascorbic acid in the conversion of proline to collagen hydroxyproline. Nature, 194, 555-557.
  3. Gale, C. R., Martyn, C. N., Winter, P. D., & Cooper, C. (1995). Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. Bmj, 310(6994), 1563-1566.
  4. Peters, E.M., et al., Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr, 1993. 57(2): p. 170-4